AGEs and Atherosclerosis

thumb_5E6822C7B45A4EC39A4EE01F9CB164CETwo studies suggest a link between AGEs (advanced glycation end-products) and the development of atherosclerosis – the buildup of fats, cholesterol and other substances in and on the artery walls.

A study published in Lipids in Health and Disease found the following:

“We found that patients with higher AGEs had more adverse atherosclerotic parameters and indexes, which suggests that AGEs could be used as a marker to predict atherosclerotic lesions. However, further studies are necessary to evaluate the clinical relevance and clinical application of AGEs testing, especially for the prevention of diabetes-related atherosclerotic diseases.”

Additionally, a study conducted at the Institute of Clinical Physiology in Italy found that AGEs promote vascular damage:

“Formation and accumulation of AGEs are related to the aging process and are accelerated in diabetes. AGEs are generated in hyperglycemia, but their production also occurs in settings characterized by oxidative stress and inflammation. These species promote vascular damage and acceleration of atherosclerotic plaque progression mainly through two mechanisms: directly, altering the functional properties of vessel wall extracellular matrix molecules, or indirectly, through activation of cell receptor-dependent signaling.”


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Copyright 2012 AGE Foundation.