shutterstock_155263265A recent study published through GreenMedInfo revealed the newest contender in the fight against AGEs—vitamin C.

The study monitored 46 subjects in their early-20s over an 8 week period, during which they were given a high dose of vitamin C daily.

The conclusion of the study states:

The daily consumption of a high dose of vitamin C for 8 weeks resulted in enhanced anti-senescence and anti-atherosclerotic effects via an improvement of lipoprotein parameters and microRNA expression through anti-oxidation and anti-glycation, especially in smokers.

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IMARSThis month, the International Maillard Reaction Society held the 12th International Symposium on the Maillard Reaction, where numerous scientists, professors and researchers presented new information relevant to the Maillard Reaction.

The Maillard Reaction is the chemical reaction between amino acids and reduced sugars that gives browned foods their flavor. It is what turns bread into toast, what makes marshmallows s’more-worthy. The delicious and seemingly harmless Maillard Reaction is a step in the formation of AGEs.

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skin_detailHealth and wellness advocates everywhere are calling for a massive reduction in general sugar intake, but their reasoning has nothing to do with weight-loss. Instead, articles insist that sugar’s main crime is its detrimental effects on the skin.

In a fascinating article published by Yahoo! Health, dermatologist Jill Waibel, MD, discusses the link between sugar and AGEs, and AGEs affect on the skin. She says:

“Eating too much sugar causes, a process that occurs when your body has excessive amount of sugar. This affects the normal function of your cells as the excess sugar molecules join together with protein molecules to create products that are foreign to your body, also known as advanced glycation end products (AGEs). Theses AGEs affect collagen and elastin, causing them to break down. As a result, wrinkles and lines form on your face.”

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shutterstock_273393155Several years ago it was discovered that consumption of red meat caused an increased risk of pancreatic cancer in men. Most assumptions behind the correlation revolve around the existence of preservatives and carcinogens found in red meats.

To shed new light on the subject, Li Jiao conducted a study to find what exactly it was that caused an increased risk of cancer.

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Mental StressAs if slowing the aging process and avoiding body-deteriorating habits weren’t enough motivation to stay away from AGEs, more and more scientists are finding a connection between these harmful metabolic byproducts and serious mental illnesses.

The presence of AGEs is often indicative of oxidative stress, which is thought to be a contributing factor in the development of diseases including schizophrenia, ADHD, Parkinson’s, Asperger’s, Alzheimer’s, autism and even cancer. In fact, AGEs are believed to speed up oxidative cell damage, thus accelerating the aging process and increasing the chance of disease development.

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AGE-Foundation-blog-cover-15-7-31-01While much attention has been given to the fact that AGEs lead to premature aging and have been connected to ailments such as diabetes and Alzheimer’s, many people might not know about some of the other harmful effects that are caused by these compounds.

For example, a recent article from The Brain Bank linked AGEs not only to diabetes, but also periodontitis, an infection that affects gums and destroys the bone that supports your teeth:

“So, why do diabetics have an increased risk of developing periodontitis? Well, Advanced Glycation End Products (AGEs) arise from chronic hyperglycaemia and therefore are common in diabetes. It is these glycated proteins or lipids which have been shown to impact on periodontal deterioration.”

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thumb_5E6822C7B45A4EC39A4EE01F9CB164CETwo studies suggest a link between AGEs (advanced glycation end-products) and the development of atherosclerosis – the buildup of fats, cholesterol and other substances in and on the artery walls.

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AGE awareness dayJune 21 marks the third annual AGE Awareness Day! AGE Awareness Day is a day dedicated to increasing awareness of AGEs and the harmful effect they have on the human body.

AGE Awareness Day wasn’t launched on June 21 by accident. The AGE Foundation specifically chose that day because it is the summer solstice – the longest day of the year. It symbolizes how properly managing your AGEs can help you live a longer, healthier life.

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donutsA recent study published in The FASEB Journal found that eating high inflammatory foods can increase AGE levels and the death risk from breast cancer.

The study conducted by Dr. Fred Tabung at the University of South Carolina was based on data from 117,510 postmenopausal women at risk of breast cancer. The participants were followed for 12.3 years during which 5,889 were diagnosed with breast cancer and 406 died.

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raw meatFor decades, scientists have warned about the dangerous carcinogens associated with grilled foods, but a new study revealed another reason to be wary of overcooking.

The study, completed by the Icahn School of Medicine at Mount Sinai Hospital, showed that a diet high in glycotoxins called advanced glycation end-products (AGEs) – found in high-concentration in well-done meat – is a risk factor in developing age-related dementia.

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women looking in mirrorAGEs naturally build up in our bodies over time, but diet and lifestyle choices can accelerate AGE accumulation and affect how quickly AGE damage manifests itself, including how quickly the effects can be seen on our skin.

Two recent articles explain how eating too much sugar increases the formation of AGEs and causes premature aging.

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Slow CookerEating a low-AGE diet doesn’t have to be boring or unsatisfying, and the Seattle Times did its part to demonstrate this with an article containing healthy recipes that can be prepared with a slow cooker.

The article is titled “Yummy slow-cooker recipes promote health, too.” It was written by Carrie Dennett, a registered dietitian nutritionist.

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Uribarri 2Mount Sinai Medical Center physician Dr. Jaime Uribarri, a member of the AGE Foundation’s advisory board, was cited in a recent article about a study published in the Journal of Alzheimer’s Disease.

The article is titled, “New study postulates the role of dietary advanced glycation end products in the risk of Alzheimer’s disease.” The study in question provides evidence that cooking foods at high temperatures increases the risk of Alzheimer’s disease, thanks to advanced glycation end-products (AGEs).

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Cut_seasoned_steaksAdvanced glycation end-products (AGEs) have been discussed by many different types of publications, and now we can add acupuncture publications to that list.

That’s because Acupuncture Today recently published the article “Meat in the Middle: Teaching Your Patients About Meat Consumption.” With its website and magazine, Acupuncture Today claims to be the only complete news source in the acupuncture profession.

The article was written by Marlene Merritt, a licensed acupuncturist who runs a wellness center in Austin, Texas. Merritt discussed various aspects of eating meat, one of which was advanced glycation end-products, which she said “conveniently have an acronym that tells us what they do … (AGE).”

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ColaandIceIf you’re still looking for a resolution to make for the new year, you may want to consider cutting back on soda or giving it up altogether. In recent months, multiple articles have been published that link soda to harmful AGEs.

One such article, which was written for Byrdie, was titled “Soda and Your Skin: New Research That Will Make You Rethink Your Drink.” Article author Deven Hopp spoke with the AGE Foundation’s very own advisory board member Dr. Brett West.

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StupidVeggieXmasThe holiday season is heavily associated with feasting on delicious food, but according to a new Cosmos article, we should also use this time to focus on good dietary health.

Cosmos is a literary science magazine published in Australia but sold internationally, and its website accumulates two million page views monthly. On December 1, the website posted the article “Season of good cheer – and guilt,” which was written by Norman Swan.

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shutterstock_109056116There is a seemingly never-ending stream of AGE-related articles in the media, with both print and online publications from all over the world educating readers about the harm that advanced glycation end-products can cause.

Many publications are talking about sugar in particular, and have stressed the importance of avoiding consuming too much sugar in our diet. The following are just a few examples that have appeared online recently.

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shutterstock_152698421Halloween and an overabundance of sweets are synonymous, but all those sweets could lead a truly scary situation – aging skin – according to a Scientific American article titled “Trick or treat … and wrinkles?

Julianne Wyrick, the author of the article, wrote:

“Mothers across the nation will likely be warning their costume-clad youngsters that they’ll ‘feel sick’ if they eat too much of the candy they collect tonight [on Halloween]. What they may not mention is that foods that raise blood sugar can also cause wrinkles, an effect dermatologist Rajani Katta calls ‘sugar sag.’”

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Pregnant Red DressA recent study has linked the consumption of fried foods by women pre-pregnancy to gestational diabetes (GDM), which is the development of high blood sugar during pregnancy despite no previous diabetes diagnosis. GDM disappears following birth, but women who suffer from it are seven times more likely to develop type 2 diabetes.

The study, which was published in the magazine Diabetologia (official journal of the European Association for the Study of Diabetes), caught the attention of many different publications. Among the websites to write about the study were Medical Daily, International Business Times, Food World News,, Lifehacker, The Telegraph,, Family Practice News, Healio, and Medical Xpress.

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GrossLookingFastFoodAccording to Food Consumer, scientists at the Universitair Ziekenhuis Brussel in Brussels, Belgium conducted a review and confirmed that advanced glycation end-products (AGEs) contribute to various health issues.

Food Consumer is an online food, diet and health news outlet. It addressed the scientists’ findings in a recent article titled “Advanced glycation end products linked to chronic inflammation.”

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PeanutsWe’ve known for a long time that advanced glycation end-products have been linked to a wide variety of health issues, whether something minor like wrinkled skin or something serious like cancer and diabetes. But a recent study suggests that AGEs may also be the reason why some people suffer from peanut allergies.

The Economist just published an article titled “Browned off” about a paper published in the Journal of Allergy and Clinical Immunology. The paper details an Oxford University study conducted by Dr. Quentin Sattentau in which mice were found to be more likely to develop a peanut allergy in response to dry-roasted nuts than in response to raw ones.

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shutterstock_134323481Daily Life, a website with news and lifestyle content for Australian women, is among the many different media sources to write about advanced glycation end-products. It did so in its recent article “How to stay youthful, inside and out,” which was written by Paula Goodyer.

Goodyer wrote:

“We might think of Botox and cosmetic repair jobs as the big guns in the anti-ageing armoury, but how about a different approach – like picking up a set of dumb bells and putting down that bag of chips? There’s growing evidence that what we do to boost our health on the inside can improve how we look on the outside too.”

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GirlChoppingTomatoIf you want to improve your health and appearance, various media sources have some advice for you: lower your advanced glycation end-product (AGE) levels.

More and more AGE-related articles have been popping up online in all regions of the world and on websites covering all sorts of topics. The following are some notable recent mentions of AGEs in the media.

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Skin Inc. describes itself as the leading industry publication for the professional skin care industry, and of course, one cannot be the leader in skin care without knowing all about advanced glycation end-products.

shutterstock_111283052Thus, Skin Inc. recently discussed AGEs in multiple articles. The company publishes a magazine for skin care facility owners and managers, and also features a weekly e-newsletter and a comprehensive website. Skin Inc. previously featured an AGE-related article in the November issue of its magazine last year.

As for its most recent AGE articles, the first was titled, “Clients With Tired, Puffy Eyes? Top Tips to More Youthful Eye Contours!

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1This time of the year is synonymous with education, since the new school year has started. Well, even if you aren’t in school anymore, there’s still the opportunity to receive a vital education in AGEs thanks to all the media coverage about these harmful compounds.

We’ve collected a sample of AGE articles from around the Internet:

Eat right, beauty (Deccan Herald): “Certain foods are bad for your skin and can make you look haggard and old. Fried, greasy, sugary foods, foods made of refined flour, foods that lack vegetables and fruits, and a diet that is largely dependent on pasta, bread and butter spells doom for your beauty.

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shutterstock_165369422It’s time for another roundup of AGE-related articles that have appeared online recently! These come from various parts of the world (the United States, United Kingdom and India) and from a variety of different sources.

The Strong Body, Strong Mind Connection (Before It’s News): “The control of blood sugar levels through the regular participation in exercise programs can also prevent advanced glycation end-products (AGEs) from forming. These AGE molecules can damage nerve cells and the connections between them, making normal brain function less likely.”

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OlderWomanTouchingFaceBig names in the world of media continue to validate what we know about advanced glycation end-products (AGEs), with Time being the latest media outlet to throw its hat into the ring (read about some other major media sources covering AGEs here).

Time has the world’s largest circulation of any weekly news magazine, with a readership of approximately 25 million. Its website just posted an article by Kiera Aaron titled “6 Foods That Can Age Your Skin.” It is a condensed version of an article titled “14 Foods That Make You Look Older,” which originally appeared on

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MagazinePileWant more proof that advanced glycation end-products are being recognized by more and more media outlets? AGEs continue to pop up in articles, blogs and news segments all over the place (like we wrote about here, here and here), and we’ve got another batch of articles to show you.

They come from a variety of sources, including Yahoo!’s Malaysian entertainment website, an online resource for inspiration and spirituality, an organization centered around integrative medicine, a Pakistani newspaper and website, and a beauty and wellness website.

Bacon Gives You Wrinkles: And Six Other Foods That Make You Age (Yahoo! Malaysia Entertainment): “It’s sad news for all the BBQ fans out there, but it turns out BBQs can make you age prematurely. Why? Well, when we cook our meat using dry heat (this includes barbequing) we produce more Advanced Glycation End products (also known as AGEs) in the foods we are cooking. AGEs speed up the ageing process. So, if you want youthful skin, skip the alfresco dining.”

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NewspaperPileAGEs are everywhere! They’re in our food, in our bodies, and also in the media. And by media, we mean that they’re being written about by all sorts of publications around the world.

Whether they’re specifically all about advanced glycation end-products, or just feature brief mentions of glycation, it isn’t hard at all to find new articles mentioning AGEs.

So, below are just a small number of articles in recent months that mention AGEs.

These 4 Foods Will Dry Your Skin, Cause Wrinkles and Kill Cells (EmaxHealth): “When sugar gets inside [our] bodies, it attaches itself to other amino groups of the tissue proteins such as collagen and slowly turns them into advanced glycation end [products] (AGE). This is a major cause of damage to the body and risk of type 2 diabetes. As a result, healthy collagen fibers lose their elasticity and become rigid, more fragile and easily destroyed. This is where the sagging skin and wrinkles come from.”

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stack of toastAGE-related articles have been popping up in the media in countries all over the world lately, and now Malaysia can be added to that list.

The Star Online recently featured an article about advanced glycation end-products titled “Beware the Maillard baddies,” which was written by Chris Chan.

The Star is Malaysia’s second-largest English newspaper and has a daily circulation of nearly 300,000. Meanwhile, its website – The Star Online – is among the most popular news sites in the country.

The “Maillard baddies” the article referred to are foods that are products of the Maillard reaction. This reaction takes place when food is fried, grilled, baked or toasted, producing a darkening effect. Examples of this are when bread is baked or toasted, or meat is charred on a grill.

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