As previously featured on this site, Cosmopolitan recently published a blog post about women’s skin care that addressed the need to avoid excess sugar because of the harmful effects of AGEs. Of course, AGEs do not discriminate against gender; men have a need to be aware of AGEs and the need for a healthy diet as well.
That was evidenced in November when the website for “Details” – a monthly men’s magazine dedicated to fashion and lifestyle – published a blog titled “4 Surprising Ways You May Be Aging Your Skin.”
“You already know that if you eat, sleep, and exercise like crap, you’re probably going to look and feel like it, too,” the article states. “But how you treat your body today can affect more than just the way you look right now; it can also impact how you’ll look in, say, 10 years.”
The November issue of Skin Inc. magazine addressed the effects of AGEs with an article titled “Glycation and the Skin.” Skin Inc. claims to be the leading industry publication for day spa, medical spa and wellness professionals, providing information about skin science, spa treatment trends, and more.
19 Nov 2013
In a recent blog titled “The Biggest Skin Care Mistakes You’re Probably Making Right Now,” Cosmopolitan explored the dos and don’ts of skin care for women. Among other topics, the article addressed AGEs and their harmful effect on skin.
21 Oct 2013
If you’re suffering from rheumatoid or osteoarthritis, research suggests Advanced Glycation End-products (AGEs) may play a role in their development.
According to researchers at the Mount Sinai School of Medicine in New York, consuming foods high in AGEs can increase inflammation in the body. While it has been known for some time that AGEs form in foods as well as the body, until recently doctors and scientists thought AGEs were created entirely inside the body. Now, however, research has shown that the body also absorbs AGEs from food consumption. An estimated 10 percent of AGEs in foods are ingested by the body.
These absorbed food AGEs have been liked to chronic diseases associated with inflammation, including rheumatoid arthritis and osteoarthritis. “We expect that increased levels of AGEs increase inflammation, although a direct link to arthritis is not firmly established,” says Dr. Jaime Uribarri, MD, the physician who controlled the study.
Additional studies have also shown that AGE production is also increased in RA patients.
The AGE Foundation is pleased to welcome the newest member of the AGE Advisory Board, Pat Baird. Ms. Baird is an award-winning author, media spokesperson, and specialist in the development and communication of information on nutrition and health issues for consumers and health care professionals.
She received her Master’s degree from New York University in Nutrition and Dietetics and is a Registered Dietitian and Fellow of the American Dietetic Association. She is an award-winning author of five books and also serves on the Board of The Dietetic Internship Program at New York-Presbyterian Medical Center and the Connecticut Academy of Nutrition and Dietetics.
In addition to her role as nutrition consultant to several global companies, Ms. Baird often serves as a media spokesperson. Her national appearances include CNN, Daily Buzz, and the CBS Morning Show, to name a few.
“Ms. Baird’s extensive knowledge and expertise in the areas of nutrition and AGEs are well-known throughout the healthcare community,” says Jeff Johnson, Vice President of the AGE Foundation. “We are excited to have her on our board and eagerly await her contributions to furthering awareness about the role of diet in AGEs.”
23 Sep 2013
World Alzheimer’s Awareness Month is dedicated to helping people learn more about Alzheimer’s and its effects. As people become more educated about Alzheimer’s disease and its symptoms, many people wonder how to tell the difference between symptoms of early stages of Alzheimer’s and memory loss associated with the normal aging process.
Forgetting an appointment or wandering around a parking lot looking for your car doesn’t necessarily mean you’re developing Alzheimer’s. Here are a few common scenarios and how to tell the difference:
Normal age-related changes
- Forgetting to pay a bill by the due date
- Needing help programming a TV or microwave
- Forgetting this day it is but remembering it later
- Not remembering a person’s name
- Forgetting where you parked your car
- Forgetting details of an experience
- Misplacing things, then retracing steps to find the
Symptoms of Alzheimer’s
- Inability to budget or manage money
- Not being able to complete basic tasks around the house
- Losing track of the month or season
- Not recognizing a family member or close friend
- Forgetting how to drive a car
- Forgetting entire experiences
- Misplacing things and not being able to retrace steps
If you notice these signs in yourself or a loved one, it’s important to see a doctor as soon as possible. Early detection can help you get the maximum benefit from available treatments.
10 Sep 2013
World Alzheimer’s Awareness month was designated to help increase awareness about the prevalence of Alzheimer’s disease and its social and economic impact. Alzheimer’s disease is a brain disease that causes progressive mental deterioration and eventual fatality. While Alzheimer’s is commonly associated with memory loss and dementia, it affects all aspects of life.
- Alzheimer’s disease is the sixth leading cause of death in the United States1
- An estimated 35.6 million people worldwide have Alzheimer’s disease2
- More than 5 million Americans are living with Alzheimer’s disease3
- 1 in 3 people over the age of 85 has dementia4
- Worldwide, a person develops Alzheimer’s every four seconds5
- Deaths from Alzheimer’s increased 68 percent between 2000 and 2010; deaths from all other major diseases (heart disease, stroke, prostate cancer, breast cancer, and HIV) decreased5
Alzheimer’s and AGEs
AGEs are significantly higher in the brains of Alzheimer’s patients than those without the disease. Growing evidence suggest that AGE accumulation in the brain causes inflammation. One study also suggested that AGEs create aggregates that interfere with healthy neuron function in the brain.
5World Health Organization
The program for the 2013 International AGE Research Symposium, which takes place this Friday in Tokyo, was released today. The program will feature the following speakers and topics:
Dr. Shixin Deng, Morinda R&D, American Fork, UT, USA
“Iridoids inhibit AGE formation”
Dr. Johannes Westendorf, retired from University of Hamburg, Germany
“Iridoids of Morinda citrifolia and their possible influence on diabetes and AGE-formation”
Dr. Yoshikazu Yonei, Doshisha University, Kyoto, Japan
“Skin AGEs and lifestyle behaviors”
Bart van den Berg, DiagnOptics, Gronigen, The Netherlands
Dr. Sho-ichi Yamagishi, Kurume University, Kurume, Fukuoka, Japan
“Role of AGEs in vascular complications in diabetes”
Dr. Vincent Monnier, Case Western Reserve University, Cleveland, OH, USA
“Advanced glycation end-products as markers of complications in diabetes”
The 2013 International AGE Research Symposium is sponsored by the AGE Foundation and AGE Measurement Promotion Association.
The AGE Foundation, in conjunction with Japan’s AGE Measurement Promotion Association, will hold the 2013 International AGE Research Symposium this Friday, August 30, at the Marunouchi Hall and Conference in Tokyo.
The event will feature renowned AGE experts, nutritionists, researchers, and doctors from around the world as they discuss AGEs and present research regarding the latest insights on the effects of iridoids on AGEs.
Following the event, several presenters will address members of the media and discuss the latest research on AGEs in the United States as well as the Japanese lifestyle and AGEs. Following the presentations, a Q&A session will be held.
A recent study indicates that alcohol increases production of a certain type of advanced glycation end-product (AGE) that induces liver damage.
Researchers at the Department of Hepatology at Kanazawa Medical University in Japan fed male rats with a liquid diet containing alcohol for 8 weeks, followed by an alcohol-free diet for 12 weeks. Following the diet, researchers compared the livers of the rats with liver biopsies from human patients with alcoholic liver disease (ALD).
During the period of time when the rats were given a diet that included alcohol, their production of acetaldehyde-derived AGEs (AA-AGEs) increased substantially. During this time, they also observed severe degeneration of the rat livers.
However, once the rats returned to an alcohol-free diet, degeneration of the liver completely disappeared and levels of AA-AGEs were absent at the end of the 12-week period.
These findings suggest that abstaining from alcohol results in the “completed disappearance of…AA-AGEs along with fatty degeneration, suggesting that AA-AGE plays a significant role in alcoholic liver disease.”
Cooking meat and other foods with dry heat (including grilling, broiling, sautéing, roasting, and baking) creates AGEs. The longer a food is cooked, the more AGEs it will contain. For this reason, it’s important to avoid overcooking your food.
At the same time, undercooking your food creates a breeding ground for unpleasant and dangerous germs, including Salmonella, botulism toxins, and other illness-causing bacteria.
The following guidelines from the United States Department of Agriculture (USDA) provides a list of minimum temperatures that indicate meat has been cooked enough to eat safely. Use these temperatures as a guide cook when cooking meat to avoid food poisoning and increased AGEs.
- Ground Meat (including beef, pork, veal, lamb, turkey, and chicken): 160° F; 71° C
- Fresh Beef, Veal, and Lamb (steaks, roasts, and chops)*: 145° F; 63° C
- Poultry (all cuts of chicken, turkey, duck, and goose: 165° F; 74° C
- Pork and Ham (fresh)*: 145° F; 63° C
- Precooked ham: reheat to 140° F; 60° C
*These foods should require a 3-minute rest time after cooking and prior to consuming
05 Aug 2013
When monitoring AGEs, we tell people to eat whole grains. But not all grains are created equal. In fact, some are downright harmful when it comes to AGE levels.
Grains you should avoid are processed grains. Processed or refined grains go through the milling process, which removed the bran and germ from the grains (and their nutritional value in the process). Grains are processed to improve their shelf life and texture.
True whole grains, on the other hand, are made up of the whole grain, which includes the bran, germ, and endosphere. In order for a food to be considered a whole grain, FDA guidelines state that at least 51% of its weight is comprised of whole grains.
Unhealthy Whole Grains
Just because a food is made with whole grains, however, doesn’t make it healthy. Cookies that uses “whole grain flour” or “whole grain” but sugary breakfast cereals still contain a host of other unhealthy additives and processed ingredients.
When you consume unhealthy grains and processed foods, blood sugar levels spike. This creates high levels of AGEs. Continually eating too many processed foods and grains can cause AGE levels to accumulate.
So how can you tell if a grain is processed? As a general rule, the ingredient list can help–the longer the list, the more processing it has gone through. Common processed grains include crackers, cookies, chips, breakfast cereal, and snack bars.
Healthy Grain Choices
When choosing whole grains, opt for those that are high in fiber. Healthy whole grain choices include whole-wheat flour, quinoa, bulgur, oatmeal, whole cornmeal, and brown rice.
When preparing your grains, you can make them even more AGE-less by steaming or boiling them.
30 Jul 2013
We already know that sun damage is one of the worst things you can do to your skin. Ultraviolet radiation from the sun (and tanning beds) is the number one cause of skin cancer. It can also break down the fibers in your skin, leading to wrinkles and premature aging. An increased awareness in the effects of the sun means more people are slathering on sunscreen and steering clear of tanning beds.
While protecting your skin from the sun is crucial for preventing skin cancer, the sun isn’t the only thing that causes your skin to wrinkle and age. AGEs are just as damaging to the skin. When excess sugar and protein combine to form AGEs, the protein becomes stiff and damaged. The proteins that keep the skin wrinkle-free are called collagen and elastin. Unfortunately, these proteins in the skin are the most susceptible to becoming AGEs. AGEs break down the collagen and elastin, causing skin to wrinkle and sag.
“When you’re younger, your body is producing more collagen and can ward off much of the damage,” says Amy Heaton, MD, PhD. “However, by the time you reach your mid-30s a build-up of sun damage, environmental oxidative stress, hormonal changes, and the accumulation of AGEs begins to take its toll at the same time your ability to repair the damage declines.”
The result? Skin starts to look old.
If you want your skin to stay young, sunscreen is a great start (and vital for skin cancer protection). Combining sun protection with a diet low in sugar and AGEs provides added defense against wrinkles, keeping your skin looking youthful and radiant.
23 Jul 2013
Expectant mothers may want to pay closer attention to the amount of AGEs they consume while pregnant. A recent study published in Free Radical Journal found that high levels of AGEs can cause complications during pregnancy, including preeclampsia and diabetes.
The study reported that as AGEs interact with their receptors in the tissues, they create an inflammatory reaction in the tissues throughout the body, including those found in the placenta. The prolonged inflammatory reactions created by AGEs led to vascular disorders during pregnancy, including preeclampsia and diabetes.
Preeclampsia is a condition that occurs during pregnancy and includes a sudden increase in blood pressure and protein in the urine. While preeclampsia is rarely fatal for the mother if treated properly, it can have negative effects on a developing fetus and is one of the leading causes of complications. Preeclampsia is linked to low birth weight, premature birth, and even still birth.
Expectant mothers should monitor AGE consumption during pregnancy by maintaining a healthy diet that avoids excessive sugar, processed foods, and high-fat meats.
In addition to diet, regular prenatal care and avoiding smoking and alcohol during pregnancy can lower your risk of preeclampsia.
18 Jul 2013
When it comes to AGEs, we spend the majority of the time discussing foods and food preparation methods as a way to avoid consuming AGEs. We know what foods we should avoid, but what about drinks? AGEs are also present in beverages, sometimes at amounts just as high as foods we should be avoiding.
As a general rule, you should avoid fattening drinks that contain high amounts of added sugar and fat. The more sugar and fat in a drink, the more AGEs it will have. Beverages with higher amounts of AGEs include:
- Flavored lattes and other high-fat, high sugar coffee-based drinks
- Energy drinks
- Whole milk
- Beverages sweetened with high-fructose corn syrup
- Hot cocoa mix
Instead, opt for these drinks low in AGEs:
- Water flavored with lemon, which has 70% fewer AGEs than soda
- Fruit juices, including apple, cranberry, and orange
- Nonfat milk
- Unsweetened of herbal tea
The way hot beverages are prepared and stored can also increase AGEs. Avoid beverages that are warmed on a heating plate for long periods of time. Coffee kept on a heating plate, for example, has 8 times the amount of AGEs than coffee prepared with the drip method.
21 Jun 2013
Beginning today, on AGE Awareness Day, one of the most innovative research technologies is taking the technological world by storm. AGE scanning research, a cutting-edge technology to help determine AGE levels in the body, will be one of the featured discussion topics at this week’s American Diabetes Association Scientific Sessions in Chicago, Illinois June 21-25.
News is spreading fast regarding the first International AGE Awareness Day. To date, over 350 news outlets across the country have featured the announcement of AGE Awareness Day, including The Wall Street Journal, The Sacramento Bee, Chicago Business Journal, The Miami Herald, The Star Tribune (Minneapolis), and hundreds more.
When it comes to health, many people are aware of the major dos and don’ts of maintaining a healthy lifestyle and diet. However, they tend to only focus on their cholesterol, blood pressure, and body mass index (BMI), and overlook another key medical marker: Advanced Glycation End-products (AGEs). If ignored, AGEs can lead to significant damage to an individual’s health over time.
27 Mar 2013
Sometimes you just have to come right out and say it: AGEs make you old and wrinkled. That’s the subject of this Business 2 Community article. If you’ve ever wanted to know the Advanced Glycation End-product (AGE) story, this is a great resource. The article takes you, step by step, through all the frequently asked questions: What is glycation? What are AGEs? How do AGEs contribute to premature aging, and so on.
26 Mar 2013
Diet plays a large role in AGE formation and accumulation. AGEs can be ingested directly through foods that have high levels of AGEs (such as browned foods, processed foods, and foods high in sugar). They also form inside the body when there is an excess amount of sugar in the blood, which happens when too much of the wrong types of foods are consumed.